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[Chemical Science] Sequestration within biomolecular condensates inhibits Aβ-42 amyloid formation
Congratulations to Andi for the publication of his work! This paper (https://doi.org/10.1039/D0SC04395H) demonstrates the complex interconnection between compartmentalization and amyloid formation. Here we show that heterotypic interactions within the compartments lead to inhibition of aggregation despite the high local increase of the concentration of the aggregation-prone protein.
[Trends in Pharmacological Sciences] Machine Learning for Biologics: Opportunities for Protein Engineering, Developability, and Formulation
Congratulations to Harini for the publication of her review! In this work (https://doi.org/10.1016/j.tips.2020.12.004), she describes the potential of machine learning in protein engineering, developability and formulation. Together with complementary approaches and advances in high-throughput experimental techniques, these methods can accelerate the development of successful biological drugs.