[Journal of Pharmaceutical Sciences] Surface-Induced Protein Aggregation and Particle Formation in Biologics: Current Understanding of Mechanisms, Detection and Mitigation Strategies

Congratulations to Marie Kopp, Fulvio Grigolato and Dominik Zürcher for the publication of their review on surface-induced protein aggregation in biologics! The review gives an overview of materials that can trigger the formation of protein particles in formulations and discusses mitigation strategies. In addition, current and emerging methods are highlighted to probe surface-induced instabilities for early-stage screening and formulation development of biologics. (external pagehttps://doi.org/10.1016/j.xphs.2022.10.009call_made)