[Nature Chemistry] The interface of condensates of the hnRNPA1 low-complexity domain promotes formation of amyloid fibrils

Phase-separated protein condensates can mature into amyloid fibrils, a process potentially associated with neurodegenerative disorders. Here, we analyze the liquid-to-solid transition of hnRNPA1, a protein linked to Amyotrophic Lateral Sclerosis. The study identifies the condensate interface as a key location promoting the formation of amyloid fibrils, providing a potential target for regulating aberrant aggregation.