[Biophysical Journal] Formation of multicompartment structures through aging of protein-RNA condensates

Cells can dynamically organize reactions through the formation of biomolecular condensates. These viscoelastic networks exhibit complex material properties and mesoscale architectures, including the ability to form multiphase assemblies. In this study, we demonstrate that the aging of initially homogeneous protein-RNA condensates can spontaneously lead to the formation of kinetically arrested double-emulsion and core-shell structures without changes in external variables such as temperature or solution conditions. To investigate this system, we combine time-resolved fluorescence-based experimental techniques with simulations based on the Cahn-Hilliard theory, have a read external page here!