[bioRxiv] De novo design of peptides localizing at the interface of biomolecular condensates
Congratulations to Timo, Marcos, Marco, and Lenka! And also congratulations to Timo for presenting the work at the conference Biomolecular condensates: From fundamental principles to applications in health and biotech in Copenhagen!
The interface of biomolecular condensates has been shown to play an important role in processes such as protein aggregation and biochemical reactions. Targeted modulation of these interfaces could, therefore, serve as an effective strategy for engineering condensates and modifying aberrant behaviors. In this study, we developed a computational pipeline that combines coarse-grained simulations, machine learning, and mixed-integer linear programming to design peptides that selectively partition at the interfaces of specific condensate targets. Using this workflow, we designed and synthesized peptides that localize at the interfaces of condensates formed by the intrinsically disordered protein regions (IDRs) of hnRNPA1, LAF-1, and DDX4. Have a read external page here!