Scalable Production and Purification of Biogenic Nanoparticles

Bioreactor

Recent clinical triumphs in gene therapy products have proven their capability to achieve life altering therapeutic results. As such, the market of gene therapy products has garnered major attention from pharmaceutical companies of all sizes.
With a wave of novel modalities, targets and therapeutics entering the market, manufacturing capabilities must evolve to provide adequate and affordable supply.
Situated at the intersection of chemistry, biology and process engineering, we develop novel methods for the scalable production and separation of biogenic nanoparticles like Extracellular Vesicles and Virus-like particles.

Contacts

Jonathan, Karl

Key publications

external page C.Paganini et al. "High‐Yield Separation of Extracellular Vesicles Using Programmable Zwitterionic Coacervates." Small, 2022

external page C. Paganini et al. "High‐yield Production of Extracellular Vesicle Subpopulations with Constant Quality Using Batch‐refeed Cultures." Advanced Healthcare Materials, 2022

external page C. Paganini et al. "Rapid Characterization and Quantification of Extracellular Vesicles by Fluorescence-Based Microfluidic Diffusion Sizing." Advanced Healthcare Materials, 2021

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