Engineering Enzymatic Reactions and Protein Aggregation by Biomolecular Condensates

Biomolecular condensates are emerging as a smart strategy evolved by cells to coordinate reactions in space and time. We aim to recapitulate this class of compartments in biotechnology to generate adaptve materials and microreactors, capable to change their composition and material properties in response to external stimuli. These programmable compartments could find applications in many areas of drug discovery, delivery and manufacturing, as well as in chemical synthesis.

Contacts

Condensates for separation and diagnostics: Jonathan, Roberto, Niccoló, Nils, Max

Key publications

external page Schneider et al. "Engineering nanocondensate formation through sequence composition and patterning" bioRxiv, 2026.

external page Papp et al. "Biomolecular condensates as regulators of enzymatic reactions"Nat. Chem. Eng., 2025.

external page Stoffel et al. "Enhancement of enzymatic activity by biomolecular condensates through pH buffering" Nat Commun, 2025.

external page Gil-Garcia et al. "Local environment in biomolecular condensates modulates enzymatic activity across length scales"Nat Commun, 2024.

external page U. Capasso Palmiero et al. 'Programmable Zwitterionic Droplets as Biomolecular Sorters and Model of Membraneless Organelles" Advanced Materials,2022